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Dr. Madhuri Koti DVM, MVSc, PhD
Dr. Madhuri  Koti
Assistant Professor
Contact Info


Department of Biomedical and Molecular Sciences

Research Interests:

Research in my lab is focused on delineating the role of tumor immune microenvironment in mediating differential drug response in cancer. Our long term goal is to identify immune mechanisms associated with therapy resistance in cancer that could be exploited to augment development of novel immunomodulatory therapies.

Selected Publications

Katrina K. Au, Nichole Peterson, Peter Truesdell, Gillian Reid-Schachter, Kasra Khalaj, Runhan Ren, Julie-Ann Francis, Charles H. Graham, Andrew W. Craig, Madhuri Koti. CXCL10 alters the tumour immune microenvironment and disease progression in a syngeneic murine model of high-grade serous ovarian cancer. Gynecol Oncol (2017),

Runhan Ren, Madhuri Koti, Thomas Hamilton, Charles H. Graham, Jasmir G. Nayak, Jas Singh, Darrel E. Drachenberg, D. Robert Siemens. (2016). A primer on tumour immunology and prostate cancer immunotherapy. Can Urol Assoc J. 10  (1-2). PMID: 26977209

Madison Black, Ivraym Barsoum, Tiziana Cotechini, Peter Truesdell, D. Robert Siemens, Madhuri Koti, Andrew Craig, Charles Graham. (2016) Activation of the PD-1/PD-L1 immune checkpoint confers chemoresistance and promotes tumor metastasis. Oncotarget. Feb 7. doi: 10.18632/oncotarget.7235. PMID: 26859684

Katrina Au, Juliana Josahikan, Julie-Ann Francis, Jeremy A. Squire, Madhuri Koti(2015)Current state of biomarkers in ovarian cancer prognosis. Future Oncology. Dec 11 (23); 3187-95. PMID: 26551891

Madhuri Koti*, Alex Siu, Isabelle Clement, Mallikarjun Bidarimath, Gulisa Turashvilli, Andrew Edwards, Anne-Marie Mes Masson, Jeremy A. Squire. (2015). A distinct pre-existing inflammatory tumor microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer. British Journal of CancerMarch 31; 112, 1215-1222. PMID: 26695556

Barsoum IB, Koti M, Siemens DR, Graham CH. Mechanisms of hypoxia-mediated immune escape in cancer. Cancer Res. 2014 Dec 15;74(24):7185-90. PMID: 25344227.

Madhuri Koti, Surinder S. Saini, Ashish Sachan and Azad K. Kaushik. Engineered Bovine Antibodies in the Development of Novel Therapeutics, Immunomodulators and Vaccines. Antibodies. 2014. 3, 205-214; doi:10.3390/antib3020205.

Jeff W Martin, Susan Chilton-MacNeill, Madhuri Koti, Andre J van Wijnen, Jeremy A Squire, Maria Zielenska. Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma. PLoS One2014 May 16;9(5). PMID: 24835790.

Koti M, Gooding RJ, Nuin P, Haslehurst A, Crane C, Weberpals J, Childs T, Bryson P, Dharsee M, Evans K, Feilotter HE, Park PC, Squire JA. Identification of the IGF1/PI3K/NF κB/ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer. BMC Cancer. 2013 Nov 16;13:549. PMID: 24237932.

Geraci J, Dharsee M, Nuin P, Haslehurst A, Koti M, Feilotter HE, Evans K. Exploring high dimensional data with Butterfly: a novel classification algorithm based on discrete dynamical systems. Bioinformatics. 2014 Mar 1;30(5):712-8. PMID: 24149051.

Haslehurst AM, Koti M, Dharsee M, Nuin P, Evans K, Geraci J, Childs T, Chen J, Li J, Weberpals J, Davey S, Squire J, Park PC, Feilotter H. EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer. BMC Cancer. 2012Mar 19;12:91. PMID: 22429801.

Weberpals JI, Koti M, Squire JA. Targeting genetic and epigenetic alterations in the treatment of serous ovarian cancer. Cancer Genet. 2011 Oct;204(10):525-35. PMID: 22137482.

Koti M, Kataeva G, Kaushik AK. A single point mutation in framework region 3 of heavy chain affects viral neutralization dynamics of single-chain Fv against bovine herpes virus type 1. Vaccine. 2011 Oct 19;29(45):7905-12. PMID: 21872632.

Koti M, Kataeva G, Kaushik AK. Novel atypical nucleotide insertions specifically at VH-DH junction generate exceptionally long CDR3H in cattle antibodies. Mol Immunol. 2010 Jul;47(11-12):2119-28. PMID: 20435350.

Koti M, Farrugia W, Nagy E, Ramsland PA, Kaushik AK. Construction of single-chain Fv with two possible CDR3H conformations but similar inter-molecular forces that neutralize bovine herpesvirus 1. Mol Immunol. 2010 Feb;47(5):953-60. PMID: 20006385.

Kaushik AK, Kehrli ME Jr, Kurtz A, Ng S, Koti M, Shojaei F, Saini SS. Somatic hypermutations and isotype restricted exceptionally long CDR3H contribute to antibody diversification in cattle. Vet Immunol Immunopathol. 2009 Jan 15;127(1-2):106-13. PMID: 19012969.

Koti M, Kataeva G, Kaushik AK. Organization of D(H)-gene locus is distinct in cattle. Dev Biol (Basel). 2008;132:307-13. PMID: 18817318.

All Departmental Publications