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Research

Queen’s University has a highly integrated health research program which operates through the jointly coordinated offices of the Vice-Dean, Research in the Faculty of Health Sciences and Vice President, Health Sciences Research at the Kingston General Hospital.  Together our institutions are committed to fostering an environment of transdisciplinary research in a number of biomedical areas and studies of population health and health services research.

Our department has a well-established research program. We are an active site in a number of industry led gynecology trials, investigator led obstetrical studies, and oncology trials through the Clinical Trials Group. We are also actively recruiting for 2 local investigator led clinical trials and several of our staff and residents are leading projects using Ontario-wide data sets available through ICES. Explore below for more information about our research projects!

Departmental Research Program Assistant:

Heather Ramshaw, BSc
ramshawh@queensu.ca
613-548-1372

Departmental Research Facilitator:

Jessica Pudwell, MPH
jessica.pudwell@queensu.ca
613-549-6666, ext 3937

Departmental Research Nurse:

Michelle Roddy, RN
michelle.roddy@kingstonhsc.ca
613-549-6666, ext 2740

Departmental Research Assistant:

Kira King, MLT, BSc
kira.king@kingstonhsc.ca
613-549-6666, ext 3937

 

The MODE Trial – Dr. Gaudet

A pilot trial investigating planned caesarean section versus induction of labour for women with class III obesity. Pregnant women, having their first baby, whose pre-pregnancy BMI was ≥40kg/m2 and planning delivery at The Ottawa Hospital or Kingston General Hospital will be eligible for recruitment in to this trial. This trial will use a Brewin partially randomized patient preference design, in which each eligible patient is asked for their preference.  Randomization will take place if no strong preference exists.

 

IV Ketamine for Pain Control During 1st Trimester Abortion – Drs. Gibson & Waddington

The purpose of this study is to determine whether a drug called ketamine would be a beneficial choice of medication for moderate sedation during first trimester surgical abortion. Ketamine is an approved medication for this type of procedure, however is not commonly used at this time. Ketamine does not carry the same risk of cardio-respiratory depression as IV opioids and midazolam. The use of ketamine could therefore improve access to optimal pain control in some clinics. We are currently recruiting women ≥18 years of age who are undergoing a first trimester abortion in the Women’s Clinic KHSC. Parallel comparison of IV ketamine, IV fentanyl and PO morphine. NTC03751423

 

Canadian study on the Association of Pessary to Progesterone (CAPP) - Drs. Smith and Gaudet

The CAPP research project is intended for pregnant women (between the 18th and 23rd week of pregnancy) whose cervix is 25 mm or less. In this study you will be randomized to progesterone only or progesterone and pessary. Visit the trial website for more information: http://capp.crc.chus.qc.ca/en_index.htm 

 

Immune Mechanisms in Women with and without Endometriosis - Drs. Tayade, Bougie, Nee and Waddington

Recruiting women with endometriosis at the time of surgery. Sample collection includes a blood sample, endometrial biopsy and peritoneal fluid. Recruiting healthy control women at the time of IUD insertion/removal (in the OR) or at the time of tubal ligation.

For more information about any of these studies please contact us!

 

The BP-MOM Trial – Dr. Smith

Recruitment to begin in Fall 2020!

A randomized open-label trial evaluating a nurse-led breastfeeding self-efficacy intervention (BSEI).  Following childbirth, breastfeeding mothers who have been diagnosed with a hypertensive disorder of pregnancy will be recruited in to the study. Women will be randomly allocated to the BSEI group or a standard postpartum care group. The trial will evaluate rates of breastfeeding, blood pressure, weight retention, postpartum depression and anxiety, and participant satisfaction at 3, 6 and 12 months postpartum. 

 

CAPTURE – Drs. Bougie and Nitsch

A multicenter prospective non-interventional study assessing the management of Canadian women with uterine fibroids, a patient registry. Recruitment complete, follow up ongoing. NCT02580578

 

RESTORELLE – Dr. Harvey

Transvaginal Mesh versus Native Tissue Repair for treatment Of Pelvic Organ Prolapse. Recruitment complete, follow up ongoing. NCT02162615

 

MIREC ENDO – Dr. Velez

Maternal-Infant Research on Environmental Chemicals: Pubertal Timing, Endocrine and Metabolic Function. Pre-pubertal follow up of our previously recruited MIREC cohort is underway. www.mirec-canada.ca/en/

 

FACT 4 Child – Dr. Smith

Follow up of children in the Folic Acid Clinical Trial (FACT) study. Follow up of our previously recruited FACT cohort is underway. NCT03269110

 

KySS – Dr. Waddington

Kyleena Satisfaction Study. Recruitment is complete, follow up is ongoing. NCT03182140