Journal Articles

2014

Bassil,K.L., A.S.Yasseen, M.Walker, M.D.Sgro, P.S.Shah, D.M.Campbell, M.Mamdani, G.N.Smith, A.E.Sprague, S.K.Lee, J.L.Maguire. The association between obstetrical interventions and late preterm birth. Am J Obstet Gynecol. 2014 Jun;210(6):538.e1-9. Epub 2014 Feb 26.2.

Rodger,M.A., M.C.Walker, G.N.Smith, P.S.Wells, T.Ramsay, N.J.Langlois, N.Carson, M.Carrier, R.Rennicks White, S.Shachkina, S.W.Wen. Is thrombophilia associated with placenta-mediated pregnancy complications? A prospective cohort study. J Thromb Haemost 2014 Apr;12(4):469-78.3.

Adamo,K.B., G.X.Shen, M.Mottola, S.Nascimento, S.Jean-Philippe, Z.M.Ferraro, K.Nerenberg, G.N.Smith, R.Chari, L.Gaudet, H.Piccinini-Vallis, C.Wolcott, S.MacDonald, S.Atkinson, A.Godbout, J.Robitaille, S.Davidge, A.Gruslin, D.Prud’homme, D.Stacey, M.Rossiter, J.Dodd. Obesity prevention from conception: a workshop to guide the development of a pan Canadian trial targeting the gestational period. Nutr Metab Insights. 2014; 7: 7–18. Published online 2014 April 3. 

Venditti CC, Smith GN.Involvement of the heme oxygenase system in the development of preeclampsia and as a possible therapeutic target. Womens Health (Lond Engl). 2014 Nov;10(6):623-43. doi: 10.2217/whe.14.54. 

Murphy MS, Vignarajah M, Smith GN. Increased microvascular vasodilation and cardiovascular risk following a pre-eclamptic pregnancy. Physiol Rep. 2014 Nov 26;2(11). pii: e12217. doi: 10.14814/phy2.12217. Print 2014 Nov 1.

Yasseen,A.S., D.B.Fell, A.E.Sprague, R.Xie, G.N.Smith, M.C.Walker, S.W.Wen. Antiviral medication use in a cohort of pregnant women during the 2009-2010 influenza pandemic. J Obstet Gynaecol. 2014 Nov 19:1-4. [Epub ahead of print] 

Venditti CC, Casselman R, Young I, Karumanchi SA, Smith GN. Carbon monoxide prevents hypertension and proteinuria in an adenovirus sFlt-1 preeclampsia-like mouse model. PLoS One. 2014 Sep 9;9(9):e106502. doi: 10.1371/journal.pone.0106502. eCollection 2014.  

Ray JG, McGeer AJ, Blake JM, Lebovic G, Smith GN, Yudin MH. Peripartum outcomes: non-adjuvanted v. adjuvanted H1N1 vaccination. CMAJ. 2014 Feb 4;186(2):137. doi: 10.1503/cmaj.114-0006.

 

2013

Wen, S.W., J.Champagne, R.Rennicks White, W.I.Fraser, G.N.Smith, D.A.Fergusson, M.C.Walker. Effect of folic acid supplementation in pregnancy on preeclampsia: the folic acid clinical trial (FACT) study. J Pregnancy 2013 doi 10.1155/2013/294312 [Epub ahead of print]. 

Magee,B., G.N.Smith. Histological Chorioamnionitis in Preterm Prelabour Rupture of Membranes at Kingston General Hospital: A Practice Audit. JOGC 2013; December.

M.Cussimano, J.Pudwell, M.Roddy, C.K.J. Cho, G.N.Smith. The Maternal Health Clinic: An initiative for cardiovascular risk reduction in women with pregnancy-related complications. Am J Obstet Gynecol 2013 Dec 4 doi 10.1016/j.ajog.2013.12.001 [Epub ahead of print].

Luo, Z.C., P.Julien, S.Q.Wei, F.Audibert, G.N.Smith, W.D.Fraser. Plasma cotinine indicates an increased risk of preeclampsia in previous and passive smokers. Am J Obstet Gynecol 2013 Oct 2. pii: S0002-9378(13)01034-X. doi: 10.1016/j.ajog.2013.09.041. [Epub ahead of print].

S.Nascimento, J.Pudwell, F.Surita, K.Adamo, G.N.Smith. The effect of physical exercise strategies on weight loss in postpartum women: a systematic review and meta-analysis. Int J Obes (Lond). 2013 Sep 19. doi: 10.1038/ijo.2013.183. [Epub ahead of print]

C.Venditti, L.Adamson, M.S.Q.Murphy, J.Sled, G.N.Smith. Chronic carbon monoxide inhalation during pregnancy augments uterine artery blood flow and uteroplacental vascular growth in mice. Am J Physiol 2013 Aug 28. [Epub ahead of print] 7.
Ray, J.G., A.J.McGeer, J.M.Blake, G.Lebovic, G.N.Smith, M.H.Yudin Peripartum outcomes: non-adjuvanted v. adjuvanted H1N1 vaccination. CMAJ. 2014 Feb 4;186(2):137.

G.N.Smith, J.Pudwell, M.Roddy. 2013: The Maternal Health Clinic: A new window of opportunity for early heart disease risk screening and intervention for women with pregnancy complications. JOGC 35(9):831-839.

G.N.Smith, G.Saade. Pregnancy as a window to future health: The development of complications in pregnancy provides a new window of opportunity for early heart disease risk screening and intervention for women. Society for Maternal-Fetal Medicine, 2013; www.smfm.org/attachedfiles/pregwindowSMFM513.pdf (pg 1-8). Highlighted ScienceDaily July 1, 2013. 10.

Arbuckle, T.E. et al., Cohort Profile: The Maternal-Infant Research on Environmental Chemicals Research Platform. Paediatric and Perinatal Epidemiology, 2013; 27(4):415-425.

Xie, H-Y, A.S.Yasseen, R.-H. Xie, A.E.Sprague, D.B.Fell, N.Liu, G.N.Smith, M.C.Walker, S.W.Wen. (2013) Infant outcomes among pregnant women who used oseltamivir for treatment of influenza during the H1N1 epidemic. Am J Obstet Gynecol Apr;208(4):293.e1-7. doi: 10.1016/j.ajog.2013.01.015. Epub 2013 Jan 17. 

Sprague, A., S.I.Dunn, D.B.Fell., J.Harold, M.C.Walker, S.Kelly, G.N.Smith (2013) Measuring Quality in Maternal-Newborn Care: Developing a Clinical Dashboard. J Obstet Gynaecol Can; Jan 35(1):29-38.

Murphy, MSQ, RC Casselman, GN Smith (2013) Postpartum alterations in circulating endothelial progenitor cells in women with a history of pre-eclampsia. Preg Hyper (In press March 2013). 


2012

Liu, N., A.E.Sprague, A.S.Yasseen, D.B.Fell, S.W.Wen, G.N.Smith, M.C.Walker. (2012) Vaccination patterns in Pregnant Women during the 2009 H1N1 Influenza Pandemic: A Population-based Study in Ontario, Canada. Can J Public Health. 2012 Jul 18;103(5):e353-8.

Wen S, H.Tan, R.Xie, G.N.Smith, M.Walker. (2012) A pre-conception cohort to study preeclampsia in China: Rationale, study design, and preliminary results. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Nov;37(11):1081-7. doi: 10.3969/j.issn.1672-7347.2012.11.001.

G.N.Smith, Gemmill,I., Moore,K.M. (2012) Management of tick bites and lyme disease during pregnancy. J Obstet Gynaecol Canada. Nov;34(11): 1087-91.

Smith GN, J.Pudwell, M.Walker and S.W.Wen for the PE-NET (2012) Risk estimation of metabolic syndrome at one and three years after a pregnancy complicated by preeclampsia. J Obstet Gynaecol Can. 2012 Sep;34(9):836-41. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET)

Smith GN, J.Pudwell, M.Walker and S.W.Wen for the PE-NET (2012) Ten year, thirty year and life-time risk estimates of cardiovascular disease following a pregnancy complicated by pre-eclampsia. J Obstet Gynaecol Canada, 34(9):830-835. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET)

Smith GN, J.Pudwell, M.Walker and S.W.Wen for the PE-NET. (2012) A history of pre-eclampsia identifies women with cardiovascular risk factors including the metabolic syndrome. Follow up of the Pre-Eclampsia New Emerging Team longitudinal prospective cohort. J Obstet Gynaecol Canada 34(9):836-841. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET)

Yanfang, G., G.N.Smith, S.W.Wen, M.C.Walker. (2012) Folate Metabolism and Preeclampsia. Fetal and Maternal Medicine Review 23:2, May 2012.

Wen SW, RH Xie, H Tan, MC Walker, G.N.Smith, R Retnakaran. Preeclampsia and gestational diabetes mellitus: pre-conception origins? Med Hypotheses. 2012 Jul;79(1):120-5. Epub 2012 Apr 26.

Fell,D.B., A.E.Sprague, N.Liu, A.S.Yasseen, S.W.Wen, G.N.Smith, M.C.Walker, Better Outcomes Registry and Network (BORN) Ontario. H1N1 influenza vaccination during pregnancy and fetal and neonatal outcomes. Am J Public Health. 2012 Jun;102(6):e33-40. Epub 2012 Apr 19. PMID:22515877

Zhai,D., Y.Guo, G.N.Smith, D.Krewski, M.Walker, S.W.Wen (2012) Maternal exposure to ambient-level carbon monoxide is associated with a decreased risk of developing preeclampsia. Am J Obstet Gynecol 2012 Jul;207(1):57.e1-9. Epub 2012 Mar 29. Selected as the “Journal Club” article-of-the-month.

Venditti, C., G.N.Smith. Self-reported smoking status as an indication of tobacco smoke exposure in pregnancy. Open Journal Obstetrics and Gynecology (OJOG). 2012, 2, 56-61. Online March 2012  

2011

Venditti, C., R. Casselman, G.N.Smith. Effects of chronic carbon monoxide exposure on fetal growth and development in mice. BMC Pregnancy Childbirth. 2011 Dec 14;11:101.

Walker, M.C., S.A.Finkelstein, R. Rennicks White, S. Shachkina, G.N.Smith, S.W.Wen, M.Rodger. (2011) The Ottawa and Kingston (OaK) Birth Cohort: development and achievements. J Obstet Gynaecol Can. Nov;33(11):1124-33.

Kozic, J.R., S.J.Benton, J.A.Hutcheon, B.A.Payne, L.A.Magee, P.vonDadelszen, Preeclampsia Integrated Estimate of RiSk Study Group. (2011) Abnormal liver function tests as predictors of adverse maternal outcomes in women with preeclampsia. J. Obstet Gynaecol Can Oct;33(10):995-1004.

Shepherd LJ, G.N.Smith.Conjoined twins nd Kingston (OaK) Birth Coho: a case report. Case Rep Obstet Gynecol. July, Article ID 235873, 3 pages, 2011. doi:10.1155/2011/235873. Epub 2011 Sep 6.

Smith GN, H McNamara, P Bessette, VM Allen, S Ross, J Schulz, R. Pierson, B. Nadeau. (2011) Resident research training objectives and requirements of the Assoc.of Academic Professionals in Obstetrics and Gynecology. J Obstet Gynaecol Can 33(10):1044-6.

Seaward, A., S.Burke, G.N.Smith, B.A.Croy.(2011) Circulating CD56+ Cells of Diabetic Women Show Deviated Homing Potential for Specific Tissues During and Following Pregnancy. Human Reproduction. 26(7):1675-84. Epub 2011 Apr12.

Kisilevsky BS, Dorland JE, Swansburg ML, Hains SM, Brown CA, G.N. Smith. (2011) Atypical fetal voice processing in preeclamptic pregnancy. J Dev Behav Pediatr. 2011 Jan;32 (1):34-40.

Guo,Y. C.J.Longo, S.W.Wen, M.C.Walker, R.Xie, Z.Sun, G.N.Smith. (2011) Cost-effectiveness of transdermal nitroglycerin use for preterm labour. Value Health. 14(2):240-6. [Epub 2011 Feb 5]

von Dadelszen P, Payne B, Li J, Ansermino JM, Broughton Pipkin F, Côté AM, Douglas MJ, Gruslin A, Hutcheon JA, Joseph KS, Kyle PM, Lee T, Loughna P, Menzies JM, Merialdi M, Millman AL, Moore MP, Moutquin JM, Ouellet AB, G.N.Smith, Walker JJ, Walley KR, Walters BN, Widmer M, Lee SK, Russell JA, Magee LA; PIERS Study Group. (2011) Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet. 2011 Jan 15; 377(9761):219-27. Epub 2010 Dec 23.

Croy BA, SD Burke, VF Barrette, J Zhang, K Hatta, GN Smith, J Bianco, AT Yamada, MA Adams. Identification of the primary outcomes that result from deficient spiral arterial modification in pregnant mice. Pregnancy Hypertens. 2011 Jan 1;1(1):87-94.

 

2010

Guo Y, Xie R, Wen SW, Walker MC, G.N.Smith (2010) Maternal transdermal nitroglycerin use and early childhood development..J Obstet Gynaecol Can. 2010 Dec; 32(12):1147-52.

G.N.Smith, Y. Guo, S.W.Wen, M.Walker for the Canadian Preterm Labour Nitroglycerin Trial Group (2010) Secondary analysis of the use of transdermal nitroglycerin for preterm labor. Am J Obstet Gynecol. 2010 Dec;203 (6):565.e1-6. 
Zhang, J., Z.Chen, G.N.Smith, B.A.Croy. (2010) Natural killer cell-triggered vascular transformation: maternal care before birth? Cell Mol Immunol. 2010 Jan;8(1):1-11. Epub 2010 Aug 16.

C.Canning, M.J.Hird, G.N.Smith (2010) The pitfalls of the “add-and-stir” approach to transdisciplinary public health research. Critical Public Health. 20 (2): 145-155. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

Zhang, H., G.N.Smith, X.Liu, J.J.A.Holden (2010) Association of MAOA, 5-HTT and NET promoter polymorphisms with gene expression and protein activity in human placentae. Physiological Genomics 2010 Jun; 42(1): 85-92. Epub 2010 Mar 23.

Schmidt Stutzman, S., C.A.Brown, S.M.J.Hains, M.Godwin, G.N.Smith, J.L.Parlow, B.S.Kisilevsky. (2010) The effects of exercise conditioning in normal and overweight pregnant women on blood pressure and heart rate variability. Biol Res Nurs. 2010 Oct;12(2):137-48. Epub 2010 Aug 26.

Xu,H., R.Perez-Cuevas, X.Xiong, H.Reyes, C.Roy, P.Julien, G.Smith, P.von Dadelszen, L.Leduc, F.Audibert, J.M.Moutquin, B.Piedboeuf, B.Shatenstein, S.Parra-Cabrera, P.Choquette, S.Winsor, S.Wood, A.Benjamin, M.Walker, M.Helewa, J.Dube, G.Tawagi, G.Seaward, A.Ohlsson, L.A.Magee, F.Olatunbosun, R.Gratton, R.Shear, N.Demianczuk, J-P.Collet, S.Wei, W.D.Fraser, INTAPP study group. (2010) An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am J Obstet Gynecol 202:239.e1-10. 


2009

Smith, G.N. (2009) Development of preeclampsia provides a window of opportunity for early cardiovascular risk screening and intervention. Expert Rev Obstet Gynecol 4(4), 355-357. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

Gaudet, L.M., M.Flavin, O.Islam, G.N.Smith (2009) Diffusion MRI brain findings in neonates exposed to chorioamnionitis: a case series. J Obstet Gynecol Can 2009 Jun;31(6):497-503. (Funded by grants from the PSI Foundation and APOG/STIRRHS)

Smith, G.N., M.C.Walker, A.Liu, S.W.Wen, M.Swansburg, H.Ramshaw, R.Rennicks White, M.Roddy, M.Hladunewich for the members of the PE-NET. (2009) A History of Pre-Eclampsia Identifies Women Who Have Underlying Cardiovascular Risk Factors. Am J Obstet Gynecol 200:58e1-48e8. (Aug 7, e pub ahead of print). (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

Robinson, L., C.Spafford, T.Graham, G.N.Smith. (2009) Acute caffeine ingestion and glucose tolerance in women with or without gestational diabetes mellitus. J Obstet Gynaecol Can. 2009 Apr;31(4):304-12. (funded by CFWH)

Liu, A., S.W.Wen, J.Bottomly, M.C.Walker, G.N.Smith (2009) Utilization of health care services of pregnant women complicated by preeclampsia in Ontario. Hypertens Pregnancy. 2009 Feb;28(1):76-84. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

Dickinson,M.A., E.L.Harnett, C.C.Venditti, G.N.Smith, (2009) Transient Lipopolysaccharide-Induced Cytokine Responses in the Maternal Serum and Amniotic fluid of Guinea Pig. Am J Obstet Gynecol 2009 May;200(5):534.e1-6. (Funded by the Physicians’ Services Incorporated (PSI) Foundation).

Chen, X.K., S.W.Wen, J.Bottomley, G.N.Smith, A.Leader, M.C.Walker (2009) In vitro fertilization is associated with an increased risk of preeclampsia. Hypertens Pregnancy. 2009 Feb;28(1):1-12. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

 

2008

Gaudet, L.M., R.Dyzak, P.Hahn, S.Chamberlain, G.N.Smith (2008) Effectiveness of acupuncture for the induction of labour at term – a pilot randomized control trial. J Obstet Gynecol Canada 2008;30(12): 1118–1123.

Wen SW, Chen XK, Rodger M, White RR, Yang Q, Smith GN, Sigal RJ, Perkins SL, Walker MC. Folic acid supplementation in early second trimester and the risk of preeclampsia. Am J Obstet Gynecol. 2008 Jan;198(1):45.el-7.

Magee, L. et al., (2008) Diagnosis, evaluation and management of the hypertensive disorders of pregnancy. J Obstet Gynecol Canada Mar;30(3 Suppl):S1. 

2007

Chen XK, Wen SW, Smith GN, Yang Q, Walker MC. New-onset hypertension in late pregnancy and fetal growth: different associations between singletons and twins. Hypertens Pregnancy. 2007; 26(3):259-72.

Chen XK, Wen SW, Smith GN, Yang Q, Walker MC. Pregnancy-induced hypertension and infant mortality in triplets. Int J Gynaecol Obstet. 2007 Jul; 98(1):10-4.

Chen XK, Wen SW, Smith GN, Yang Q, Walker M. Pregnancy-induced hypertension and infant mortality: Roles of birthweight centiles and gestational age. BJOG.   2007 Jan;114(1):24-31.

Magee, L. et al for the CHIPS Pilot Trial Collaborative Group. (2007) The Control of Hypertension In Pregnancy Study pilot trial. BJOG. 114(6):770, e13-20.

MacDonald, S., M.Walker, H.Ramshaw, M.Godwin, X.-K.Chen, G.N.Smith. (2007) Survey of Obstetrical Care providers understanding of long term risks and follow up of women with hypertensive disorders in pregnancy. J Obstet Gynecol Canada 29: 705-710. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

Yang T., S.W. Wen, M.C. Walker, M.A. Beduz, P.C.W. Kim for the Fetal Alert Network (2007) Women’s satisfaction with the current state of prenatal care for pregnancies complicated by fetal anomalies: A survey of five academic perinatal units in Ontario. J Obstet Gynecol Canada 29:308-314.

Menzies J. et al., for the PIERS Study Group. (2007) Instituting surveillance guidelines and adverse outcomes in preeclampsia: a single site study. Obstet Gynecol 110:121-127.

Rodger M.A. et al., For the TIPPS Investigators. (2007) Long Term Dalteparin in Pregnancy is Not Associated With A Decrease In Bone Mineral Density: A Sub-Study of a Randomized Controlled Trial. J Thromb Haemost 5:1600-1606.

Menzies J, L.A. Magee, Y.C. MacNab, J.M. Ansermino, J. Li, M.J. Douglas, A. Gruslin, P. Kyle, S.K. Lee, M.P. Moore, J.M. Moutquin, G.N. Smith, J.J. Walker, K.R.Walley, J.A.Russell, P.von Dadelszen. (2007) Current CHS and NHBPEP criteria for severe preeclampsia do not uniformly predict adverse maternal or perinatal outcomes. Hypertension in Pregnancy 2007, Vol. 26, No. 4, 447-462.

Kim, P.C.W., M.Walker, G.N.Smith, et al. (2007) Fetal Alert Network (FAN): An Integrated Population Based Fetal Care Network ; Linking Conception to Outcome. Pediatrics Child Health 12:369-372.

Yang, T., S.W.Wen, M.C.Walker, M.A.Beduz, P.C.Kim for the Fetal Alert Network (2007) Women’s satisfaction with the current state of prenatal care for pregnancies complicated by fetal anomalies: A survey of five academic perinatal units in Ontario. JOGC 29:308-314. 

Sidle, E., R. Casselman, G.N.Smith (2007) The Effect of Cigarette Smoke on Placental Antioxidant Expression. Am J Physiol Regul Integr Comp Physiol 293(2):R754-8 (May 23; Epub). Ahead of print) (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

Harnett, E.L. M.A.Dickinson, G.N.Smith (2007) Dose-Response LPS-Induced Fetal Brain Injury in the Guinea Pig. Am J Obstet Gynecol 197:179e1-179e7. (Funded by the PSI Foundation)

Belkacemi, L., S.Bainbridge, M.Dickinson, G.N.Smith, C.Graham. (2007) Nitroglycerin inhibits hypoxia/reoxygenation-induced apoptosis in the syncytiotrophoblast of the human placenta: therapeutic implications for pre-eclampsia. Am J Pathol 170(3):909-20 (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET)

Smith, G.N. and M.C.Walker. (2007) Canadian Preterm Labour Nitroglycerin Trial. Am J Obstet Gynecol, 197:325-6 (In Response).

Smith, G.N., S.Packenham, S.Chamberlain (2007) Women’s views of elective primary caesarean section. J Obstet Gynecol Canada, 29:214-216 (In Response).

Smith, G.N., M.C.Walker, R.Windrim, K.O’Brien, A.Ohlsson for the Canadian Perinatal Network (2007) Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor. Am J Obstet Gynecol 197:37.e1-37.e8 (Editors’ Choice article…see accompanying editorial: Iams, J.D. 2007;197:4) (CIHR MCT-41550). 


2006

Bainbridge, S.A., L.Belkacemi, M.Dickinson, C.H.Graham, G.N.Smith. (2006) Carbon Monoxide Inhibits Hypoxia/Re-oxygenation Induced Apoptosis and Secondary Necrosis in Syncytiotrophoblast. Am J Pathol 169;774-783. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET). Editors’ Choice article.

Bainbridge, S.,G.N.Smith (2006) Effect of nicotine on the in vitro human placental perfusion pressure. Can J Physiol Pharmacol 84;953-7. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

Chen XK, Wen SW, Smith G, Leader A, Suntandar M, Yang Q, Walker M. Maternal age, paternal age and new-onset hypertension in late pregnancy. Hypertens Pregnancy. 2006; 25(3):217-27.

Chen XK, Wen SW, Smith G, Yang Q, Walker M. New-onset hypertension in late pregnancy is associated with lower fetal infant mortality in preterm twins. Hypertens Pregnancy. 2006; 25(3):205-15.

Chen XK, Wen SW, Smith G, Yang Q, Walker M. Pregnancy-induced hypertension is associated with lower infant mortality in preterm singletons. Br J Obstet Gynecol.2006; 113:554-51.

Yang Q, Wen SW, Smith GN, Chen Y, Krewski D, Chen XK, Walker MC.   Maternal cigarette smoking and the risk of pregnancy-induced hypertension and eclampsia. Int J Epidemiol. 2006; 35:288-93.

Chen XK, Yang Q, Smith G, Krewski D, Walker M, Wen SW. Environmental lead level and pregnancy-induced hypertension. Environ Res. 2006 Mar;100(3):424-30. Epub 2005 Aug 29.

Luo,Z.C, W.D.Fraser, C.I.Deal, P.Julien, F.Audibert, G.N.Smith, X.Xiong, M.Walker. (2006) Tracing the origins of “fetal origins” of adult disease: Programming by Oxidative Stress? Medical Hypothesis, 66: 38-44.

Gaudet, L. and G.N. Smith (2006) Abetalipoproteinemia in pregnancy. JOGC 28:716-719.

 

2005

Swansburg, M.L., C.A.Brown, S.M.M.Hains, G.N.Smith, B.S.Kisilevsky. (2005) Comparison of maternal cardiac autonomic function and fetal heart rate in preeclamptic and normotensive pregnancies: An exploratory study. Can J Cardiovasc Nursing, 15:42-52. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET).

Ahmed,H., B.E.McLaughlin, J.Soong, G.N.Smith, G.S.Marks, J.F.Brien, K.Nakatsu. (2005) The source of endogenous carbon monoxide formation in human placental chorionic villi. Cell Mol Biol (Noisy-le-grand) 51:447-51.

Smith, G.N. for the Canadian Perinatal Network. (2005) Prevalence, Management and Outcomes of women who present with preterm premature rupture of the membranes. J Obstet Gynecol Canada 27;547-553.

Tam, L.E., S.D.McDonald, S.W.Wen, G.N.Smith, R.C.Windrim, M.C.Walker. (2005) A survey of periconceptional folic acid use in a group of Canadian women. J Obstet Gynecol Canada. 27: 232-236.

Cockwell, H., G.N. Smith. (2005) Emergency Cerclage: Case Series and Review of the Literature. J Obstet Gynecol Canada;27:123-129.

Bainbridge, S., E. Sidle, G.N.Smith (2005) Direct placental effects of cigarette smoke protect women from pre-eclampsia: the specific roles of carbon monoxide and antioxidant systems in the placenta. Medical Hypothesis. 64; 17-27. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET)

Bainbridge, S., G.N. Smith. (2005) The Role of the Heme-oxygenase System in Pregnancy. Free Radical Biology and Medicine. 38:979-988. (PE-NET: CIHR FMI 63194 and HSFC PG-03-0175-PE-NET)  


2004

Wen, S.W., G.N.Smith, Q.Yang, M.Walker. Epidemiology of preterm birth and neonatal outcome. Seminars in Fetal & Neonatal Medicine. 2004 (9), 429-435.

Alkazaleh, F., S. Viero, M. Simchen, M. Walker, G.Smith, C.Laskin, R.Windrim, J.Kingdom. (2004) Second Trimester Sonographic Recognition Of Placental Damage And Treatment With Heparin. Ultrasound in Obstetrics & Gynecology. 23:472-476.

Patrick, L.A., L.M.Gaudet, A.E.Farley, J.P.Rossiter, L.L.Tomalty, G.N.Smith (2004) Development of a Guinea Pig Model of Chorioamnionitis and Fetal Brain Injury. Am J Obstet Gynecol; 191: 1205-1211. (funded by the PSI Foundation and the OFCP) 

Farley, A., C.Graham, G.N.Smith. (2004) Contractile properties of human anchoring villi. Am J Physiol; 287: R680-R684. 


2003

Appleton, S.D., G.E. Lash, G.S. Marks, K. Nakatsu, J.F. Brien, G.N. Smith, and C.H. Graham. (2003) Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells. Amer. J. Physiol. 285:R1453-1460.

Bustard, M., A. Farley, B.Bennett, G.N. Smith. (2003) Steady-state maternal and fetal plasma concentrations of glyceryl trinitrate (GTN) in the preterm sheep. Can J Physiol Pharmacol 81:884-889. (funded by the PSI Foundation).

Bustard, M., G.Ryan, M.E.Salenieks, G.N.Smith (2003) Human Maternal and Fetal Plasma Glyceryl Trinate Concentrations. Am J Obstet Gynecol 189: 1777-1778. (funded by the PSI Foundation).

B.E. McLaughlin, G.E. Lash, G.N. Smith, G.S. Marks, K. Nakatsu, C.H. Graham, and J.F. Brien. (2003) Heme oxygenase expression in selected regions of term human placenta. Exp. Biol. Med., 228:564-567.

Appleton, S.D., G.S.Marks, K.Nakatsu, and J.F.Brien, G.N.Smith, C.H.Graham, G.E. Lash. (2003) The effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells. Am J Physiol 284: H853-H858.

Lash, G.E., B.E.McLaughlin, S.MacDonald-Goodfellow, G.N.Smith, J.F.Brien, G.S.Marks, K.Nakatsu, C.H.Graham. (2003) Relationship between tissue damage and hemeoxygenase expression in the human placenta. Am J Physiol Heart Circ Physiol 284: H160-H167.

Bustard, M., B.Bennett, G.N.Smith (2003) Pharmcokinetics of nitroglycerin in pregnancy. Am J Obstet Gynecol, 188:1118-1119. 

2002

Ferguson, S.E., G.N.Smith, M.E.Salenieks, R.Windrim, M.Walker. (2002) Preterm, premature rupture of membranes: Nutritional and Socioeconomic Factors. Obstetrics & Gynecology 100: 1250-6.

Appleton, S.D., G.S.Marks, K.Nakatsu, and J.F.Brien, G.N.Smith, C.H.Graham. (2002) Heme oxygenase activity in the placenta: Direct dependence on oxygen availability. Am J Physiol Heart Circ Physiol 282:H2055-H2059.

Patrick, L. and G.N.Smith. (2002) Proinflammatory cytokines: A link between Chorioamnionitis and Fetal Brain Injury. JOGC 24:705-709.

Bainbridge, S., A. Farley, B. MacLaughlin, K. Nakatsu, G. Marks, J.F.Brien, G.N.Smith. (2002) Carbon monoxide decreases perfusion pressure in isolated human placenta. Placenta 23:563-569.

Bustard, M., A. Farley, G.N. Smith. (2002) The pharmacokinetics of glyceryl trinitrate with the use of the in vitro human placental perfusion set up. Am J Obstet Gynecol 187:187-190.

Smith, G.N., M.Walker. (2002) Commentary: Single vs Multiple courses of antenatal corticosteroids. J Obstet Gynecol Canada, 24: 339-341.

McLaughlin, B.E., G.E.Lash, C.H.Graham, G.N.Smith, H.J.Vreman, D.K.Stevenson, G.S.Marks, K.Nakatsu, J.F.Brien. (2001) Endogenous Carbon Monoxide formation by chorionic villi of term human placenta. Placenta 22:886-888.

2001

Walker, M., G.N. Smith, M. Rodger,J.C. Kingdom. (2001). Thrombophilia and adverse obstetrical outcome. J Obstet Gynecol Canada 23: 683-694.

Gaudet, L., G.N. Smith. (2001) Cerebral Palsy and Chorioamnionitis: The Inflammatory Cytokine Link. Obstet Gynecol Survey 56: 433-436.

Ferguson, S.E., G.N. Smith, M.C. Walker. (2001) Maternal plasma homocysteine levels in women with preterm premature rupture of membranes. Med Hypoth 56:85-90. 

2000

McLaughlin, B.E., J.M. Hutchinson, C.H. Graham, G.N. Smith, G.S. Marks, K. Nakatsu, J.R. Brien. (2000) Heme Oxygenase activity in the term placenta. Placenta 21:870-873.

Smith, G.N., J.C. Kingdom, D.H. Penning, S.G. Matthews. (2000) Antenatal corticosteroids: Is more better?. Lancet 355:251-252.

Smith, G.N. and M.C. Walker. (2000) Nitroglycerin as a tocolytic. Br J Obstet Gynaecol 107: 1182-1183.  

1999

Smith, G.N., Walker, M., K. Fung Kee Fung. (1999) The Canadian Perinatal Network: a proposal. J SOGC 50: 1-5.

Walker, M., G.N.Smith, E. Keely, P.Garner. (1999) Changes in homocysteine levels in normal pregnancy. Am J Obstet Gynecol 180:660-664.

Smith, G.N., M. Walker, M.J. McGrath. (1999) Randomized, double-blind, placebo controlled pilot study assessing nitroglycerin as a tocolytic. Br J Obstet Gynecol 106:736-739. 

1998

Smith, G.N. & J.F. Brien. (1998) The Use of Nitroglycerin for Uterine Relaxation. Obstet Gynecol Survey 53: 559-565.

Smith, G.N. and M.C. Walker. (1998) The idea of Immunity. Am. J. Obstet. Gynecol. 178: 418. 

1997

Smith, G.N., M. Walker, J.L. Tessier, K. Millar (1997) Increased incidence of preeclampsia in women conceiving by intrauterine insemination using donor versus partner sperm for treatment of primary infertility. Am J Obstet Gynecol 177: 455-458. 

1996

Smith, G.N., M. Walker, S. Johnston, and K. Ash. (1996) The sonographic finding of persistent umbilical cord cystic masses is associated with lethal aneuploidy and/or congenital anomalies. Prenatal Diagnosis 16: 1141-1147. Selected to be abstracted in Mosby Year Book of Neonatal and Perinatal Medicine, 1998.

Smith, G.N. and J. Drover. (1996) Non-Obstetrical Surgery in the Pregnant Patient. SOGC. 18: 997-1007. 

1995 - 1987

Bobier, H.S., G.N. Smith, S.R. Pancham, and J.F. Brien. (1995) Comparative study of sodium nitroprusside-induced vasodilation of human placental veins from normotensive and preeclamptic pregnancy. Can. J. Physiol. Pharmacol. 73: 1118-1122.

Smith, G.N. and W.N. Piercy. (1995) Methyldopa Hepatotoxicity in Pregnancy: A Case Report. Am. J. Obstet. Gynecol. 172: 222-224.

Bocking, A.D., L.J. Carmichael, S. Abdollah, K.R. Sinervo, G.N. Smith, and J.F. Brien. (1994) Effect of ethanol on immature ovine fetal breathing movements, fetal prostaglandin E2, and myometrial activity. Am J. Physiol. 266; (Regulatory Integrative Comp. Physiol.): R1297 - R1301.

Bocking, A.D., K.R. Sinervo, G.N. Smith, L. Carmichael, J.R.G. Challis, D.M. Olson, and J.F. Brien. (1993) Increased uteroplacental production of prostaglandin E2 during ethanol infusion. Am. J. Physiol. 265; (Regulatory Integrative Comp. Physiol. 34): R640 - R645.

Sinervo, K.R., G.N. Smith, A.D. Bocking, J. Patrick, and J.F. Brien. (1992) Effect of ethanol on the release of prostaglandins from ovine fetal brain stem during gestation. Alcohol. Clin. Exp. Res. 16; 443-448.

Smith, G.N., K.R. Sinervo, L. Carmichael, J. Patrick, A.D. Bocking, and J.F. Brien. (1991) The effects of indomethacin and prostaglandin E2 on the ethanol-induced suppression of ovine fetal breathing movements. J. Dev. Physiol., 16: 239-242. 

Smith, G.N., J. Patrick, K.R. Sinervo, and J.F. Brien. (1991) Effects of ethanol on the embryo/fetus: experimental considerations, mechanisms and the role of prostaglandins. Can. J. Physiol. Pharmacol., 69: 550-569.

Treissman, D., G.N. Smith, J. Patrick, and J.F. Brien. (1990) Effect of ethanol on 15-hydroxyprostaglandin dehydrogenase activity in the brain stem of the near-term fetal sheep. Dev. Pharmacol. Therapeut., 16: 48-52.

Smith, G.N., J.F. Brien, J. Homan, L. Carmichael, D. Treissman, and J. Patrick. (1990) Effect of ethanol on ovine fetal and maternal plasma prostaglandin E2 concentrations and fetal breathing movements. J. Dev. Physiol. 14: 28-36.

Smith, G.N., J.F. Brien, J. Homan, L. Carmichael, and J. Patrick. (1990) Indomethacin reversal of ethanol-induced suppression of ovine fetal breathing movements and relationship to prostaglandin E2. J. Dev. Physiol. 14: 37-45.

Smith, G.N., J. Patrick, and J.F. Brien. (1990) Functional tolerance to the effects of ethanol on fetal biophysical activities? Am. J. Obstet. Gynecol. 162: 1631-1632.

Smith, G.N., J.F. Brien, J. Homan, L. Carmichael, and J. Patrick. (1989) Indomethacin antagonizes the ethanol-induced suppression of breathing activity but not the suppression of brain activity in the near-term fetal lamb. J. Dev. Physiol. 12: 77-85.

Smith, G.N., J.F. Brien, L. Carmichael, D.W. Clarke, and J. Patrick. (1989) Effect of acute, multiple-dose ethanol on maternal and fetal blood gases and acid-base balance in the near-term pregnant ewe. Can. J. Physiol. Pharmacol. 67: 686-688.

Smith, G.N., J.F. Brien, L. Carmichael, J. Homan, D.W. Clarke, and J. Patrick. (1989) Development of tolerance to ethanol-induced suppression of breathing movements and brain activity in the near-term fetal lamb during short-term maternal administration of ethanol. J. Dev. Physiol. 11: 189-197.

Clarke, D.W., G.N. Smith, J. Patrick, B. Richardson, and J.F. Brien. (1989) Activity of alcohol dehydrogenase and aldehyde dehydrogenase in maternal liver, fetal liver, and placenta of the near-term pregnant ewe. Dev. Pharmacol. Therap. 12: 35-41.

Patrick, J., L. Carmichael, B. Richardson, G. Smith, J. Homan, and J.F. Brien. (1988) Effects of multiple-dose maternal ethanol infusion on fetal cardiovascular and brain activity in lambs. Am. J. Obstet. Gynecol. 158: 1424-1429.

Clarke, D.W., G.N. Smith, J. Patrick, B. Richardson, and J.F. Brien. (1988) Disposition of ethanol and its proximate metabolite, acetaldehyde, in the near-term pregnant ewe for short-term maternal administration of moderate-dose ethanol. Drug Metab. Disposit. 16: 464-468.

Brien, J.F., D.W. Clarke, G.N. Smith, B. Richardson, and J. Patrick. (1987) Disposition of acute, multiple-dose ethanol in the near-term pregnant ewe. Am. J. Obstet. Gynecol. 157: 204-211.

Clarke, D.W., J. Patrick, M.E. Wlodek, G.N. Smith, B. Richardson, and J.F. Brien. (1987) The role of fetal urinary excretion in the transfer of ethanol into amniotic fluid after maternal administration of ethanol to the near-term pregnant ewe. Can. J. Physiol. Pharmacol. 65: 1120-1124.

All Departmental Publications